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ABSTRACT Objectives To adapt the adult spinal deformity frailty index (ASD-FI), which was presented as an instrument for stratification of risk of surgical complications, for application in the Brazilian population. Methods This is a consensus-building study, following the Delphi method, in which a team of six Brazilian spine surgery specialists worked alongside the International Spine Study Group (ISSG), the group responsible for preparing the original version of the ASD-FI, in order to adapt the index for the Brazilian population. The variables to be included in the new version, as well as the translation of the terminology into Portuguese, were evaluated and a consensus was considered to have been reached when all (100%) of the Brazilian experts were in agreement. Results A version of the ASD-FI was created, composed of 42 variables, with the inclusion of two new variables that were not included in the original version. The new version was then back translated into English and approved by the ISSG members, resulting in the adapted version of the ASD-FI for the Brazilian population. Conclusion This study presents an adapted version of the adult spinal deformity frailty index for the Brazilian population, for the purpose of risk stratification in the surgical treatment of these complex deformities. Level of evidence II; Study of adaptation of a valid score.
RESUMO Objetivos Adaptar o Índice de Fragilidade para Deformidade da Coluna Vertebral do Adulto (IF-DCVA), apresentado como instrumento para estratificação de risco para complicações cirúrgicas, para aplicação na população brasileira. Métodos Trata-se de um estudo de criação de consenso, seguindo o método Delphi, em que uma equipe de seis especialistas brasileiros em cirurgia da coluna trabalhou em conjunto com o International Spine Study Group (ISSG), grupo responsável pelo desenvolvimento da versão original do IF-DCVA, a fim de adaptar o índice para a população brasileira. As variáveis a serem incluídas na nova versão, assim como a tradução da terminologia para o português foram avaliadas e foi considerado consenso quando todos (100%) os especialistas brasileiros chegaram a um acordo. Resultados Uma versão do IF-DCVA foi criada, composta por 42 variáveis, com a inclusão de duas novas variáveis que não faziam parte da versão original. A nova versão foi, então, retrotraduzida para o inglês e aprovada pelos membros do ISSG, resultando na versão adaptada do IF-DCVA para a população brasileira. Conclusões O presente estudo apresenta uma versão adaptada do Índice de Fragilidade para Deformidade da Coluna Vertebral do Adulto para a população brasileira com o objetivo de avaliar a estratificação de risco no tratamento cirúrgico dessas deformidades complexas. Nível de evidência II; Estudo de adaptação de um escore válido.
RESUMEN Objetivos Adaptar el Índice de Fragilidad para Deformidad de la Columna Vertebral del Adulto (IF-DCVA), presentado como instrumento para estratificación de riesgo para complicaciones quirúrgicas, para aplicación en la población brasileña. Métodos Se trata de un estudio de creación de consenso, siguiendo el método Delphi, en el que un equipo de seis especialistas brasileños en cirugía de columna trabajó junto con el International Spine Study Group (ISSG), grupo responsable por el desarrollo de la versión original de IF-DCVA, a fin de adaptar el índice para la población brasileña. Las variables a ser incluidas en la nueva versión, así como la traducción de la terminología para el portugués de Brasil fueron evaluadas y se consideró consenso cuando todos (100%) los especialistas brasileños llegaron a un acuerdo. Resultados Fue creada una versión del IF-DCVA, compuesta por 42 variables, con la inclusión de dos nuevas variables que no formaban parte de la versión original. La nueva versión fue entonces retrotraducida al inglés y aprobada por los miembros del ISSG, lo que resultó en la versión adaptada del IF-DCVA para la población brasileña. Conclusiones El presente estudio presenta una versión adaptada para la población brasileña del Índice de Fragilidad para la Deformidad de la Columna Vertebral del Adulto, con el objetivo de evaluar la estratificación de riesgo en el tratamiento quirúrgico de esas deformidades complejas. Nivel de evidencia II; Estudio de adaptación de una escala válida.
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Humans , Scoliosis , Aging , FrailtyABSTRACT
Purpose: Prevalence of Clostridium difficile, an anaerobic, Gram-positive, spore-forming bacillus, is very much underestimated in India. The present study was intended to assess the burden of toxigenic C. difficile in hospitalised patients with clinically significant diarrhoea and analysis of their clinical picture. Materials and Methods: This cross-sectional study was conducted in a tertiary care teaching hospital, South India, from January 2012 to December 2014. Stool samples were collected consecutively from 563 inpatients from various wards. The prevalence of toxigenic C. difficile was determined by toxigenic culture and a two-step algorithm. The clinical spectrum of these patients was also analysed. Associated pathogens were identified using standard procedures. Statistical analysis was done by frequency, percentage, Chi-square test and z-test. Results: Out of the 563 stool samples analysed, the prevalence of toxigenic C. difficile was 12.79% and that of non-toxigenic C. difficile was 10.83%. The prevalence of toxigenic C. difficile among oncology patients was highly significant (HS). Antibiotic treatment, prolonged hospital stay and underlying diseases/conditions were the risk factors which were HS, and fever was the significant clinical feature among the patients. Escherichia coli was the predominant associated pathogen isolated (18.47%). Conclusion: The presence of toxigenic C. difficile in our locality is a matter of concern. Constant supervision, appropriate treatment and preventive measures are crucial in controlling C. difficile infection.
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ABSTRACT Objective: To assess the intra- and inter-observer reliability of a Brazilian Portuguese translated and cross-culturally adapted version of the mJOA questionnaire. Methods: The reliability of the Brazilian Portuguese version of the mJOA scale was assessed through the evaluation of a sample of patients with cervical myelopathy by two independent experienced spine surgeon examiners. Inter-observer reliability was defined by the Intraclass Correlation Coefficient (ICC) between the evaluations of the two examiners, and intra-observer reliability was assessed by the ICC between the two evaluations of one examiner. Results: Fifty-five patients were included in the study (mean age 58.7 years). The ICC for inter-observer reliability of the Brazilian Portuguese version of the mJOA was 0.967, and the ICC for intra-observer reliability was 0.869, both classified as "almost perfect" (> 0.81). Conclusion: The Brazilian Portuguese translated and cross-culturally adapted version of the mJOA questionnaire appears to be valid and reliable. Level of evidence I, Diagnostic Studies, Investigating a Diagnostic Test.
RESUMO Objetivo: Avaliar a confiabilidade intra e interobservador da versão do questionário mJOA traduzida e adaptada culturalmente para o português brasileiro. Métodos: A confiabilidade da versão em português da escala mJOA foi avaliada em uma amostra de pacientes com mielopatia cervical por dois examinadores com experiência em cirurgia da coluna vertebral. A confiabilidade interobservador foi definida pelo Coeficiente de Correlação Intraclasse (CCI) entre as avaliações dos dois examinadores e a confiabilidade intraobservador pelo CCI entre duas avaliações de um examinador. Resultados: Cinquenta e cinco pacientes foram incluídos no estudo (média de idade: 58,7 anos). O CCI para confiabilidade interobservador da versão brasileira do mJOA foi 0,967 e o CCI para a confiabilidade intraobservador foi 0,869, ambas classificadas como "quase perfeita" (> 0,81). Conclusão: A versão do questionário mJOA traduzida e adaptada culturalmente para o português brasileiro demonstrou-se válida e confiável. Nível de Evidência I, Estudos diagnósticos, Investigação de um Exame para Diagnóstico.
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PURPOSE: Whereas continuous renal replacement therapy (CRRT) has been utilized during liver transplantation (LT), there was a lack of evidence to support this practice. We investigated the adverse events at the perioperative periods in recipients of LT who received preoperative CRRT without intraoperative CRRT. METHODS: We retrospectively reviewed medical records of adult patients (age ≥ 18 years) who received LT between December 2009 and May 2015. Perioperative data were collected from the recipients, who received preoperative CRRT until immediately before LT, because of refractory renal dysfunction. RESULTS: Of 706 recipients, 42 recipients received preoperative CRRT. The mean (standard deviation) Model for end-stage liver disease score were 49.6 (13.4). Twenty-six point two percent (26.2%) of recipients experienced the serum potassium > 4.5 mEq/L before reperfusion and treated with regular insulin. Thirty-eight point one percent (38.1%) of recipients were managed with sodium bicarbonate because of acidosis (base excess 5.5 mEq/L), refractory acidosis, or critical arrhythmias. Mortality was 19% at 30 day and 33.3% at 1 year. CONCLUSION: Although intraoperative CRRT was not used in recipients with severe preoperative renal dysfunction, LT was safely performed. Our experience raises a question about the need for intraoperative CRRT.
Subject(s)
Adult , Humans , Acidosis , Arrhythmias, Cardiac , Hyperkalemia , Insulin , Liver Diseases , Liver Transplantation , Liver , Medical Records , Mortality , Perioperative Period , Potassium , Renal Replacement Therapy , Reperfusion , Retrospective Studies , Sodium Bicarbonate , Transplant RecipientsABSTRACT
OBJECTIVES: To develop a version of the modified Japanese Orthopaedic Association (mJOA) scale that had been translated into Portuguese and cross-culturally adapted for the Brazilian population. METHODS: The well-established process of forward-backward translation was employed along with cross-cultural adaptation. RESULTS: Three bilingual translators (English and native Portuguese) performed the forward translation of the mJOA scale from English to Portuguese based on iterative discussions used to reach a consensus translation. The translated version of the mJOA scale was then back-translated into English by a native English-speaking translator unaware of the concepts involved with the mJOA scale. The original mJOA scale and the back-translated version were compared by a native North American neurosurgeon, and as they were considered equivalent, the final version of the mJOA scale that had been translated into Portuguese and cross-culturally adapted was defined. CONCLUSION: To facilitate global and cross-cultural comparisons of the severity of cervical myelopathy, this study presents a version of the mJOA scale that was translated into Portuguese and cross-culturally adapted for the Brazilian population.
Subject(s)
Humans , Cross-Cultural Comparison , Quality of Life , Spinal Cord Diseases/diagnosis , Translations , Brazil , Reproducibility of Results , Severity of Illness Index , Surveys and QuestionnairesABSTRACT
<p><b>INTRODUCTION</b>This prospective observational study compared the postoperative analgesic effectiveness of intrathecal morphine (ITM) and surgical-site infusion (SSI) of ropivacaine as adjuncts to intravenous (IV) patient-controlled analgesia (PCA) (fentanyl) in living-donor kidney transplant recipients.</p><p><b>METHODS</b>Patients undergoing living-donor kidney transplantation who received ITM or SSI in addition to IV PCA were included. Rescue analgesia was achieved with IV meperidine as required. The primary outcome, measured using the Numeric Pain Rating Scale (NRS), was pain at rest and when coughing. Patients were assessed for 48 hours after surgery.</p><p><b>RESULTS</b>A total of 53 patients (32 ITM, 21 SSI) were included in the study. The ITM group showed significantly lower NRS scores, at rest and when coughing, for up to 12 and eight hours. NRS scores were comparable between the groups at other times. The ITM group had significantly less postoperative systemic opioid requirement in the first 24 hours, but there was no significant difference between the systemic opioid consumption of the groups on postoperative Day 2. In the ITM group, 3 (9.4%) patients presented with bradypnoea and 1 (3.1%) with excessive sedation in the first 12 postoperative hours. More patients in the ITM group developed pruritus requiring treatment during the first 24 hours. There were no differences between the groups in other outcomes (e.g. nausea/vomiting, change in pulmonary or kidney functions).</p><p><b>CONCLUSION</b>Compared with SSI, ITM reduced immediate postoperative pain and IV opioid consumption on postoperative Day 1 after living-donor kidney transplantation, but at the cost of increased pruritus and respiratory depression.</p>
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OBJECTIVES: To determine whether contraceptive discontinuation is associated with pregnancies that are conceived earlier than desired (mistimed) or are not wanted at the time of conception (unwanted). METHODS: Data were obtained from the 2002 Guatemala National Maternal and Child Health Survey. Pregnancies within the three years prior to and at the time of the survey (April 1999-November 2002) were classified as either "intended," "mistimed," or "unwanted." The key independent variable was whether the woman had used contraception within 12 months of the pregnancy and, for those who had used it, the reason for discontinuation (either to get pregnant or for another reason). A multinomial logistic analysis was used to determine the degree of association of discontinuation with pregnancy intentions. RESULTS: One of every five mistimed pregnancies and one of every six unwanted pregnancies followed discontinuations that were for reasons other than to become pregnant (e.g., contraceptive failure, side effects, and health concerns). Discontinuations for reasons other than to become pregnant were shown to be positively and significantly associated with a reported mistimed pregnancy (coefficient = 2.15; standard error = 0.27) or unwanted pregnancy (2.68; 0.37) compared to an intended pregnancy. Pregnancies preceded by discontinuations for reasons other than to become pregnant were also more likely to be reported as mistimed or unwanted than pregnancies of women who were not using contraception during the year prior to pregnancy. CONCLUSIONS: There is a need to increase contraceptive continuation. Any program should include an increased effort to reduce contraceptive failure and better address the side effects and the health concerns that women have that can lead to discontinuation. Non-users who want to delay or limit births should also be identified and targeted for outreach in order to reduce unintended pregnancies.
OBJETIVOS: Determinar si la suspensión del uso de anticonceptivos (SUA) está asociada con embarazos concebidos antes de lo deseado (inoportunos) o no deseados. MÉTODOS: Se usaron los datos de la Encuesta Nacional de Salud Materna e Infantil en Guatemala de 2002. Los embarazos registrados entre los tres años previos a la encuesta (desde abril de 1999) y el final de la misma (noviembre de 2002) se clasificaron como deseados, inoportunos o no deseados. La variable independiente principal fue si la mujer había usado algún anticonceptivo en los 12 meses previos al embarazo y, en ese caso, la razón de la SUA (para lograr un embarazo u otra razón). Mediante el análisis logístico polinominal se determinó el grado de asociación entre la SUA y el tipo de embarazo resultante. RESULTADOS: Uno de cada cinco embarazos inoportunos y uno de cada seis embarazos no deseados sucedieron a la SUA por razones ajenas al deseo de un embarazo (por ejemplo, fallas o efectos secundarios del anticonceptivo, o consideraciones de salud). Se encontró una asociación directa y significativa entre la SUA por razones ajenas al deseo de quedar embarazada y los embarazos clasificados como inoportunos (coeficiente = 2,15; error estándar = 0,27) o no deseados (2,68; 0,37), en contraste con los embarazos deseados. Las mujeres que suspendieron el uso de anticonceptivos por razones ajenas al deseo de un embarazo presentaron una mayor probabilidad de considerar sus embarazos inoportunos o no deseados que las mujeres que no emplearon medios anticonceptivos en el año previo a su embarazo. CONCLUSIONES: Es necesario promover el uso continuado de los anticonceptivos. Los programas deben hacer un mayor esfuerzo para reducir las fallas de los anticonceptivos, informar mejor sobre los efectos secundarios y aclarar las preocupaciones sanitarias que puedan llevar a la SUE. A fin de reducir el número de embarazos no programados, se deben identificar y captar a las mujeres que no usan anticonceptivos...
Subject(s)
Adolescent , Adult , Female , Humans , Pregnancy , Contraception , Pregnancy, Unwanted , GuatemalaABSTRACT
OBJETIVO: O presente estudo teve como objetivo relacionar as adaptações fisiológicas proporcionadas pela atividade física e os níveis de fadiga em pacientes portadores de câncer. MATERIAL E MÉTODOS: Vinte e sete pacientes (56,7 ± 14,8 anos) diagnosticados com câncer e que participavam de tratamento de quimioterapia, de radiação ou de uma combinação desses dois tipos de tratamentos foram os voluntários neste projeto. Todos os pacientes participaram de duas avaliações físicas: uma antes do início do programa de exercícios físicos e outra seis meses após. Nos dias das avaliações físicas, os pacientes responderam ao questionário de escala de fadiga de Piper et al. (1989). Todas as variáveis independentes (adaptações fisiológicas) foram padronizadas (escores Z). De acordo com o modelo de regressão linear múltipla, todas as variáveis independentes foram inseridas no modelo simultaneamente. RESULTADOS: Os resultados não demonstraram relação significativa (p < 0,01) na variação da redução de fadiga (r² = 0,102). Após o resultado não significativo da análise de regressão linear múltipla, os resultados das correlações simples também não demonstraram resultados significativos. CONCLUSAO: Apesar de a melhora na aptidão física dos pacientes com câncer não ter apresentado correlação significativa com a redução da fadiga, a relação entre a melhora do condicionamento físico geral em pacientes com câncer mostrou um padrão positivo e linear.
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Humans , Male , Female , Exercise , Exercise Therapy , Muscle Fatigue , Neoplasms/complicationsABSTRACT
PURPOSE: We tried to elucidate antitumor effect of interleukin-2 containing miscrospheres (IL-2 MS) against intrahepatic challenge of parental cancer cells, which is clinically relevant tumor model. MATERIALS AND METHODS: Using a model of liver metastasis by intrahepatic challenge of CT-26 murine colon carcinoma cells to syngeneic BALB/c mice, IL-2 MS were given with parental tumor cells, or intratumorally in animals with established tumors. Tumor volume and survivals were determined. RESULTS: Animals receiving IL-2 MS showed significant tumor suppression effect and systemic protection against the hepatic challenge of parental tumor cells after concomitant challenge with parental CT-26. In animals with established hepatic tumors, significant prolongation in survival was noted. CONCLUSION: IL-2 MS was effective for the protection of host agaisnt the metastatic hepatic tumor when administered with tumor cells. Its efficacy against the established tumor was also significant as in protection. Locally administered IL-2 MS can obviate the high- efficiency gene transfer technique and ex vivo culture of autologous tumor cells in gene transduced autologous tumor vaccine. It can also provide support for the specific immuno- therapy for the metastatic liver cancer.